Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP. , , , , , , , , , , , , ,
Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities. Bubak MP, Davidyan A, O’Reilly CL, Mondal SA, Keast J, Doidge SM, Borowik AK, Taylor ME, Voloviceva E, Kinter MT, Britton SL, Koch LG, Stout MB, Lewis TL Jr, Miller BF. bioRxiv 2024.03.01.582957; doi:10.1101/2024.03.01.582957. Preprint.
Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. 2024). doi: 10.1038/s41467-024-46463-w. PMID: 36993655. * Equal Contribution.
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration. J Appl Physiol (1985). 2023 Jan 1;134(1):181-189. doi: 10.1152/japplphysiol.00611.2022. Epub 2022 Dec 15. PMID: 36519568
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Redox Biol. 2022 Nov 26;59:102550. doi: 10.1016/j.redox.2022.102550. Online ahead of print. PMID: 36470129
Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion. Front Mol Neurosci. 2022 Nov 2;15:1042616. doi: 10.3389/fnmol.2022.1042616. eCollection 2022. PMID: 36407767. * Equal Contribution
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Nat Commun. 2022 Aug 1;13(1):4444. doi: 10.1038/s41467-022-32130-5. PMID: 35915085
Necroptosis increases with age in the brain and contributes to age-related neuroinflammation. Geroscience. 2021 Sep 13. doi: 10.1007/s11357-021-00448-5. Online ahead of print. PMID: 34515928
Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed. Neuron. 2021 Aug 4:S0896-6273(21)00505-5. doi: 10.1016/j.neuron.2021.07.006. PMID: 34384519
Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation. Cell Rep. 2021 Apr 13;35(2):108952. doi: 10.1016/j.celrep.2021.108952. PMID: 33852851
Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease. Rangaraju V*, Lewis TL Jr*, Hirabayashi Y*, Bergami M*, Motori E*, Cartoni R*, Kwon SK*, Courchet J*. J Neurosci. 2019 Oct 16;39(42):8200-8208. doi: 10.1523/JNEUROSCI.1157-19.2019. PMID:31619488 * Equal Contribution
MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. Lewis TL Jr*, Kwon SK*, Lee A, Shaw R, Polleux F. Nat Commun. 2018 Nov 27;9(1):5008. doi: 10.1038/s41467-018-07416-2. PMID:30479337 * Co-first Authors
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice.
Courchet V, Roberts AJ, Meyer-Dilhet G, Del Carmine P, Lewis TL Jr, Polleux F, Courchet J. Nat Commun. 2018 Oct 16;9(1):4289. doi: 10.1038/s41467-018-06584-5. PMID:30327473
Emerging roles of mitochondria in synaptic transmission and neurodegeneration. Lee A, Hirabayashi Y, Kwon SK, Lewis TL Jr, Polleux F.Curr Opin Physiol. 2018 Jun 3:82-93. doi: 10.1016/j.cophys.2018.03.009. PMID:30320242
Structure and Function of an Actin-Based Filter in the Proximal Axon. Balasanyan V, Watanabe K, Dempsey WP, Lewis TL Jr, Trinh LA, Arnold DB. Cell Rep. 2017 Dec 5;21(10):2696-2705. doi: 10.1016/j.celrep.2017.11.046. PMID: 29212018
Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Di Nardo A, Turner D, Lewis TL Jr, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Cell Rep. 2016 Oct 18;17(4):1053-1070. doi: 10.1016/j.celrep.2016.09.054. PMID: 27760312
Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo. Lewis TL Jr, Turi GF, Kwon SK, Losonczy A, Polleux F. Curr Biol. 2016 Oct 10;26(19):2602-2608. doi: 10.1016/j.cub.2016.07.064. Epub 2016 Sep 15. PMID: 27641765
Virus-Enabled Optimization and Delivery of the Genetic Machinery for Efficient Unnatural Amino Acid Mutagenesis in Mammalian Cells and Tissues. Zheng Y, Lewis TL Jr, Igo P, Polleux F, Chatterjee A. ACS Synth Biol. 2017 Jan 20;6(1):13-18. doi: 10.1021/acssynbio.6b00092. Epub 2016 Aug 9. PMID: 27482719
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Toyama EQ*, Herzig S*, Courchet J, Lewis TL Jr, Losón OC, Hellberg K, Young NP, Chen H, Polleux F, Chan DC, Shaw RJ. Science. 2016 Jan 15;351(6270):275-281. doi: 10.1126/science.aab4138. PMID: 26816379 * Co-first Authors
LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. Kwon SK, Sando R 3rd, Lewis TL, Hirabayashi Y, Maximov A, Polleux F. PLoS Biol. 2016 Jul 18;14(7):e1002516. doi: 10.1371/journal.pbio.1002516. eCollection 2016 Jul. PMID: 27429220
Cell biology in neuroscience: Cellular and molecular mechanisms underlying axon formation, growth, and branching. Lewis TL Jr*, Courchet J*, Polleux F. J Cell Biol. 2013 Sep 16;202(6):837-48. doi: 10.1083/jcb.201305098. Review. PMID: 24043699 * Co-first Authors
Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Courchet J*, Lewis TL Jr*, Lee S, Courchet V, Liou DY, Aizawa S, Polleux F. Cell. 2013 Jun 20;153(7):1510-25. doi: 10.1016/j.cell.2013.05.021. PMID: 23791179 * Co-first Authors
Neuronal morphogenesis: Golgi outposts, acentrosomal microtubule nucleation, and dendritic branching. Lewis TL Jr, Polleux F. Neuron. 2012 Dec 6;76(5):862-4. doi: 10.1016/j.neuron.2012.11.019. PMID: 23217734
A role for myosin VI in the localization of axonal proteins. Lewis TL Jr, Mao T, Arnold DB. PLoS Biol. 2011 Mar;9(3):e1001021. doi: 10.1371/journal.pbio.1001021. Epub 2011 Mar 1. PMID: 21390300
Myosin-dependent targeting of transmembrane proteins to neuronal dendrites. Lewis TL Jr, Mao T, Svoboda K, Arnold DB. Nat Neurosci. 2009 May;12(5):568-76. doi: 10.1038/nn.2318. Epub 2009 Apr 19. PMID: 19377470
The role of Kif5B in axonal localization of Kv1 K(+) channels. Rivera J, Chu PJ, Lewis TL Jr, Arnold DB. Eur J Neurosci. 2007 Jan;25(1):136-46. PMID: 17241275